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The answer is 5. infusion rate 1.54 mgs/min
Since the amount in the blood stream at any time, t is y(t), and
Since the anti-biotic will be eliminated from the bloodstream at a rate proportional to the amount y(t) present in the bloodstream at time t, we have that
-dy(t)/dt ∝ y(t)
-dy(t)/dt = ky(t) where k = proportionality constant = rate constant
Now, k = 0.693/t where t = half-life of antibiotic = 3 hours = 3 × 60 min = 180 min.
Since the rate at which the antibiotic is eliminated from the blood equals the infusion rate and we require an amount of y(t) = 400 mgs, the infusion rate is
dy(t)/dt = ky(t)
dy(t)/dt = 0.693 × 400/180
dy(t)/dt = 277.2/180
dy(t)/dt = 1.54 mgs/min
So, the infusion rate is 1.54 mgs/min
So, the answer is 5. infusion rate 1.54 mgs/min
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