A client is receiving an infusion of alteplase for an intra-arterial clot. The client begins to mumble and is disoriented. What action by the nurse is most important?
a. Assess the client's neurologic status.
b. Notify the Rapid Response Team.
c. Prepare to administer vitamin K.
d. Turn down the infusion rate.

When a client receiving an infusion of alteplase for an intra-arterial clot begins to show signs of neurologic changes such as mumbling and disorientation, the most important action by the nurse is:

b. Notify the Rapid Response Team.

These signs could indicate a potential complication such as intracranial bleeding or a worsening of the patient's condition. It is crucial to involve the Rapid Response Team immediately so that the patient can receive prompt assessment and appropriate intervention. Assessing the client's neurologic status (option a) is important, but it should not delay the activation of the Rapid Response Team. Options c and d are not appropriate actions in this situation, as administering vitamin K or adjusting the infusion rate would not address the potential serious complication of intracranial bleeding. Therefore, option b is the most important action to take in this scenario.