The Apolipoprotein a1-Milano mutation produces a more efficient protein that aids in the transport of cholesterol through the blood and may improve organism survival (i.e., reduces the risk of cardiovascular disease).
ApoA1-M (apolipoprotein A1-Milano) is a human apoA1 mutant that is the significant convecting protein of the HDL macromolecule. ApoA1-M is created as a result of arginine 173 to cysteine replacement, conferring antithrombotic and cardiovascular disease protection.
Independent of LDL and HDL cholesterol levels, an increased ApoA1-M (apolipoprotein A1-Milano) ratio increases the likelihood of atherosclerotic cardiovascular disease due to malfunctions in the transport of cholesterol through the blood.
Apolipoprotein A-1 Milano is a found naturally mutated variant of the apolipoprotein A1 protein discovered in human HDL, the lipoprotein particle that transports cholesterol from tissue to the liver and is linked to coronary heart disease protection.
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