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The Williamson Ether synthesis is a reaction that uses deprotonated alcohol.
What is Williamson Ether Synthesis?
The general method for ether synthesis, Williamson's ether synthesis, involves nucleophilic displacement of a halide ion or other well-formed group by an alkoxide ion. The name of the reaction was coined after Alexander William Williamson developed it in 1850. The Williamson Ether Synthesis is a reaction that uses deprotonated alcohol and an organohalide to form an ether.
- The Williamson Ether synthesis usually occurs as an SN2 reaction of primary alkyl halides with alkoxide ions. The ether structure was proved due to this chemical reaction.
- The SN2 pathway is required for synthesis, this reaction is useful only when the alkyl halide is primary or secondary.
- The ether produced in this way has more carbon atoms than either of the starting materials and thus has a more complex structure.
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