10. takai, t. 2002. roles of fc receptors in autoimmunity. nat. rev. immunol. 2: 580–592. 11. lucas, m., x. zhang, v. prasanna, and d. m. mosser. 2005. erk activation following macrophage fcgammar ligation leads to chromatin modifications at the il-10 locus. j. immunol. 175: 469–477

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14-09-2022
Biology

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10. takai, t. 2002. roles of fc receptors in autoimmunity. nat. rev. immunol. 2: 580–592. 11. lucas, m., x. zhang, v. prasanna, and d. m. mosser. 2005. erk activation following macrophage fcgammar ligation leads to chromatin modifications at the il-10 locus. j. immunol. 175: 469–477

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Tutorconsortium358 Tutorconsortium358 · Answer 1 · 2022-09-18T10:45:45+02:00

Since the discovery of Fc Receptors and their purpose, it has been forty years. IgG receptors (FcR), high-affinity IgE receptors (FcRI), IgA and IgA/IgM receptors, and neonatal Fc receptor for IgG are all examples of Fc receptors (FcRn).

Particularly, the FcRs have a well-established involvement in the development of immune-mediated disorders as well as numerous biological processes connected to the response to infection and cancer.
It has been suggested that Fc receptors, and FcRs in particular, which set a threshold for immune cell activation, have both positive and negative regulatory functions.
When it comes to the transport of IgG through polarized epithelial barriers at mucosal surfaces and the regulation of IgG half-life, Fc receptors, like FcRn, have a new shape and function.
The potential efficacy of targeting Fc receptors for medicinal purposes is highlighted by these various roles.
The most recent data on this biology's therapeutic applications is compiled in this review.

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