Respuesta :
This is most likely due to differences between strains in:
MHC proteins
Immunological Variations from C57BL/6 to BALB/c
-Innate immunological responses between C57BL/6 and BALB/c vary, particularly between type 1 and type 2 helper T cells (Th1 and Th2). Th1 immune response and IFN production are crucial in C57BL/6 mice. --Alternatively, the Th2 immune response, which is frequently seen in allergy reactions and infectious illnesses, is simpler to induce in BALB/c mice.
-Compared to C57BL/6 mice, BALB/c mice tend to elicit a higher humoral response.
-At the H2 location of the major histocompatibility (MHC)class I gene locus, these strains have different gene sequences; BALB/c mice are H2d, whereas C57BL/6 are H2b.
-The H2 locus is the site of genetic variation between these two strains. Certain monoclonal antibodies (mAbs) must be utilized to do this since some antiserum or antibodies that may respond to the cells of both strains cannot distinguish between the MHC haplotype.
-The difference in Listeria monocytogenes sensitivity between C57BL/6 and BALB/c mice can be attributed to variations in dendritic cells' early interleukin 12 (IL-12) production.
C57BL/6 mouse: Low incidence of various tumors: There is a low natural incidence (0% -1%)for breast cancer, and it is difficult to cause cancer with carcinogens.
BALB/c: This strain of mouse has a low incidence (3%) for breast cancer, while the rate increased when induced by the mouse mammary tumor virus(MMTV).
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