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Hemophilia is a genetic disorder caused by the recessive allele of a diallelic X-linked gene. Hemophilic men carry the recessive allele in their X chromosome. The man XhY is hemophilic.
What is hemophilia?
Hemophilia is a hemorrhagic affection that occurs because the blood does not coagulate as it should in normal conditions.
Hemophilia is a genetic X-linked disorder caused by the recessive form of a diallelic gene.
- The recessive allele h codes for hemophilia,
- The dominant allele is H and codes for the normal phenotype.
In the case of women, this gene expresses complete dominance, meaning that an heterozygous woman is normal but carrier.
Any man who gets the X chromosome carrying the recessive allele expresses the affection.
Let us represent the dominant allele H with the symbol + and the recessive allele h with the symbol -.
Genotypes Phenotypes
X⁺X⁺ Normal woman
X⁺X⁻ Normal and carrier woman
X⁻X⁻ Hemophilic woman
X⁺Y Normal man
X⁻Y Hemophilic man
In the exposed exposed example, the individual XhY is a man that expresses hemophilia, since he has the X chromosome carrying the recessive allele.
The phenotype displayed in the individual whose genotype is XhY is hemophilia.
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