Mutations that lead to protein disruption will produce defective proteins by affecting the first level (amino acid sequence). Defective proteins are non-functional.
A mutation is any alteration in the nucleotide sequence of the genome (i.e., the genetic material) of an organism.
Mutations in genes may lead to the generation of different types of proteins that encode for different amino acids.
The first level of protein structure is the amino acid sequence, thereby mutations may affect this level.
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