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this classification of drug typically changes the brain's chemistry and reduces its ability to create its own endorphins

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Regular use of opioids may reduce the brain's production of endorphins.
beautylovers789

This classification of drug typically changes the brain's chemistry and  

reduces its ability to create its own endorphins.

options:

Stimulants

Depressants

Hallucinogens

Narcotics


I believe the answer is Hallucinogens  but Hallucinogens  can be considered to be Narcotics so its out of those two.

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