First you could switch the order of the numbers were the two fractions are that would now be 1/4 + 4/3(-12)
when you add 1/4 + 4/3 you would get 1 7/12. then you would do 1 7/12 x -12. Multiplying is easy just go straight across. but since its whole and mixed number you would put a one under the -12.
1 7/12 x -12 is -19