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___________________ is the most powerful natural stimulant; its use produces euphoria, restlessness, and excitement, while overdoses can cause delirium, violent manic behavior, and respiratory failure.

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The correct answer is Cocaine

Explanation:  Cocaine causes an intense and rapid euphoria that is immediately followed by the opposite - intense depression, tension and greed for more drugs. People who consume it do not eat or sleep properly. They may experience a very high heart rate, muscle spasms and seizures.