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Apply Scientific Reasoning What are some possible reasons a cell might not be able to
create and deliver all the protein it needs? Come up with at least four potential reasons and
discuss specific cell structures and their functions

Respuesta :

KerryM

Answer:

Gene mutations

Low level of transcription

Not enough amino acids

Problems with protein trafficking

Explanation:

Mutations in genes or their surrounding regulatory elements could affect the transcription of the gene or the sequence of the mRNA. For example, mutations in the gene regulatory elements could affect the binding of transcription factors that affect gene transcription. This would in turn affect the abundance of mRNA. Alternatively, a deletion in the gene could result in an incomplete and non-functional protein being produced. While a mutation would only directly affect one protein, it could have a knock on effect on a variety of others

In the nucleus, if gene transcription is low, the cell will not produce enough mRNAs, which are translated into protein. This could happen if, for example, the level of RNA polymerase or another important factor in transcription, are low. If the transcription machinery is not producing enough mRNA, then the protein synthesis machinery in the cytoplasm will not have templates from which to make proteins

Amino acids are important building blocks of proteins. Not all of the amino acids can be produced by the cell, some of them have to be obtained from our diet. For example, valine. If there is not a sufficient pool of valine in the cell, then the tRNA will not be able to deliver valine to the ribosome quickly enough to growing mRNA chains. This means the protein synthesis machinery can't keep up with the demands of the cell, resulting in less protein being synthesised.

The Golgi apparatus is an important organelle in the trafficking of proteins. Proteins reach the Golgi apparatus, and are enclosed in membrane-bound vesicles, where they are delivered to the sites they are required, for example, proteins are secreted outside the cell in this way. A problem with the Golgi apparatus would mean proteins cannot be secreted outside the cell properly. The Golgi apparatus is known to be dysfunctional in Alzheimer's disease, for example.

luisvaschetto

A cell might not be able to create and deliver proteins due to mutations, which are capable of altering signaling pathways, transcription, translation and epigenetic gene expression patterns.

  • A mutation is any alteration in the DNA (nucleotide) sequence of the genome of a cell in an organism.

  • A mutation may alter the transcription of a nucleotide sequence from DNA to mRNA.

  • Mutations also can produce errors in translation (e.g., a mutation that alters the binding between ribosome and mRNA).

  • A mutation may lead to the production of a defective protein, thereby hampering the signaling pathway in which this protein is involved.

  • Finally, a mutation in an epigenetic agent (e.g., a histone acetyltransferase) can lead to the repression of a gene and therefore hamper its normal expression.

In conclusion, a cell might not be able to create and deliver proteins due to mutations, which are capable of altering signaling pathways, transcription, translation and epigenetic gene expression patterns.

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