Which of these hypothetical scenarios are examples of pleiotropy?

A. A single gene determines the size and color of a plant's flowers.
B. A defect in a single gene causes a disease in which affected individuals have longer limbs and vision problems.
C. A single gene determines whether or not an individual is color blind.
D. A defect in a single gene causes a disease in which affected individuals have longer limbs.
E. Multiple genes determine the skin color of an individual.