Chargaff's Rule tells us that in DNA, adenine binds to thymine and cytosine binds to guanine. To which part of the nucleotide do these refer?

These are the nitrogenous bases in a nucleotide. There are four, which you mentioned in the problem: adenine, thymine, guanine, and cytosine.

The other two parts of a nucleotide make up he backbone: sugar, deoxyribose (DNA=DEOXYRIBOnucleic acid) and the phosphate group.

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aliasger2709 aliasger2709 · Answer 2 · 2022-01-13T11:38:51+01:00

Chargaff gave the rule for the base pairing between the purines and pyrimidines of nucleic acid and stated that they are in the proportionate of 1:1 in any organism.

It refers to the nitrogenous bases of the nucleotide.

What are nucleotide and base-pairing rules?

The nucleic acids are formed on the structural blueprint of sugar, nitrogenous bases and phosphate. In DNA deoxyribonucleic acid sugar along with phosphate and purines (A, G) and pyrimidines (C and T ) is present.

In DNA the purine adenine always binds with the thymine and the guanine always binds with the pyrimidine cytosine.

Thus, nitrogenous bases are where the rule applies.

Learn more about Chargaff's Rule here:

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