How does your body respond differently the second time in exposed how does your body respond differently the second time exposed to a pathegon than the first time it was exposed to the same pathogen

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Imagine a chemist is in the lab and trying to make some chemical reactions happen. In one reaction she reacts chemicals in an exothermic reaction and there is an increase in entropy. A second chemical reaction she is trying to run is endothermic and there is a decrease in entropy. Which of the two reactions is more likely to occur and why?