Answer;
- large-scale changes in chromosome structure
Explanation;
-Alterations to chromosome structure or changes in the number of copies of chromosomes in a cell.
-Allele frequencies in a population may change due to four fundamental forces of evolution: Natural Selection, Genetic Drift, Mutations and Gene Flow. Mutations are the ultimate source of new alleles in a gene pool. Mutation is important as the first step of evolution because it creates a new DNA sequence for a particular gene, creating a new allele.
