Describe the steps you would take to make a transgenic mouse in which a native gene can be immediately been replaced by a mutant, on demand. We want to add an inducer to the drinking water, so that the mouse loses expression of the native protein and it is replaced with the expression of the recombinant one. Use RNAi (shRNA method) and Cre-loxP. The native gene, expressed only in the brain, is a neuronal cell surface receptor gene called "5-HT2A" which is a receptor for the drug LSD and responsible for its psychological effects. The mutant "5-HT2Amut" does not bind LSD. We want to induce the mutant , silence the native. Then test for LSD sensitivity. Use drawings and text responses in your answer.