Which of the following statements are TRUE when you compare and contrast the pathogenicity of Clostridium botulinum and Clostridium tetani?
1) Both produce neurotoxins that interfere with motor control.
2) Both bacteria are anaerobic endospores-formers that produce neurotoxins.
3) Tetanus toxin, produced by C. tetani, targets inhibitory neurons, and blocks inhibitory neurotransmitters, resulting in muscles of contracting spasmodically, and sometimes lock in continuous contraction, resulting in non-flaccid paralysis.
4) Botulism toxin, produced by C. botulinum, prevent muscular contraction by preventing the secretion of acetylcholine in the neuromuscular junction which prevents signaling to muscle cells. When muscle cells do not receive signals from motor neurons, they remain relaxed, which result in a flaccid paralysis.