Which of the following statements regarding determining binding and SAR is correct?
A) An alkene group can be reduced to its alkyl analogue under H2 gas with palladium on charcoal as the catalyst. A drug molecule has a linear hydrocarbon chain. Producing an analogue with branched hydrocarbon chain does not require synthesis of the full molecule. An alkene group may interact with the drug target via hydrogen bond.
B) An amide can be reduced to amine by using sodium borohydride (NaBH4). A cyclohexyl ring can act as a hydrogen bond acceptor.
C) Producing an analogue with branched hydrocarbon chain requires synthesis of the full molecule. An amide group may interact with the drug target via hydrogen bond.
D) An alkene group can be reduced to its alkyl analogue under H2 gas with palladium on charcoal as the catalyst. A cyclohexyl ring can act as a hydrogen bond acceptor.