Drug therapy to improve symptoms of peripheral artery disease (PAD) despite antiplatelet and statin therapy may include:
a) Cilostazol, a phosphodiesterase inhibitor that improves walking distance and symptoms in intermittent claudication
b) Pentoxifylline, a methylxanthine derivative that improves blood flow and reduces blood viscosity
c) Naftidrofuryl oxalate, a vasodilator that improves walking distance and symptoms in intermittent claudication
d) Rivaroxaban, a direct oral anticoagulant that may reduce thrombotic events in patients with PAD